There was significant increase in cyclosporine AUC, Cmax, Cmin 24-hour concentration and significant reduction in apparent oral clearance following the administration of fluconazole. In several studies in which pregnant rats were treated orally with fluconazole during organogenesis, maternal weight gain was impaired and placental weights were increased at 25 mg kg. There was mean SD increase in tolbutamide AUC of 26 range: 12 to 39. Generic Diflucan is used to treat yeast infections of the mouth, throat, and vaginal yeast fungal urinary tract pneumonia embryonic by and fungal infections throughout the whole body and in the blood. Fluconazole Clinical Pharmacology Pharmacokinetics and Metabolism The pharmacokinetic properties of Fluconazole are similar following administration by the intravenous or oral routes. Esophageal kaufen fluconazole zahlen kabeljau candidiasis: The recommended dosage of Fluconazole for esophageal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.